John Matsoukas

Professor (Organic Chemistry)

Diploma in Chemistry

University of Patras, Patras, Greece (1971).

Ph.D in Chemistry

University of Patras, Patras, Greece (1978). 

 ·     Peptides : Synthesis, activity and conformational investigation of peptide hormones. (Angiotensin II, TRAP, MBP, GnRH).

·     Spectroscopy : NMR techniques (2D-NMR, COSY, TOCSY, ROESY, NOESY).

·     Medicinal Chemistry : Design and synthesis of peptide mimetics based on receptor models.

1.  T. Tselios, L. Probert, I. Daliani, E. Matsoukas, A. Troganis, I. Gerothanassis, T. Mavromoustakos, G. Moore and J.      Matsoukas. "Desing and Synthesis of a Potent Cyclic Analogue of the Myelin Basic Protein Epitope MBP72-85 :      Importance of the Ala81 Carboxyl Group and of a Cyclic Conformation for Induction of Experimental Allergic      Encephalomyelitis (E.A.E.)". J. Med. Chem. 1999, 42, 1170-1177.

2.  T. Mavromoustakos, A. Kolocouris, M. Zervou, P. Roumelioti, J. Matsoukas, R. Weisemann. "An Effort to Understand  the Molecular Basis of Hypertension Through the Study of Conformational Analysis of Losartan and Sarmesin Using a     Combination of Nuclear Magnetic Resonance Spectroscopy and Theoretical Calculations". J. Med. Chem. 1999, 42, 1714-1722.

3.  K. Alexopoulos, P. Fatseas, E. Melissari, D. Vlahakos, J. Smith, T. Mavromoustakos, M. Saifeddine, G. Moore, M.      Hollenberg, J. Matsoukas. "Design and Synthesis of Thrombin Receptor-Derived Non-Peptide Mimetics Utilizing a      Piperazine Scallold". Bioorg. and Med. Chem. 1999, 7, 1033-1041.

4.  Antagonists. P. Roumelioti, T. Tselios, K. Alexopoulos, T. Mavromoustakos, A. Kolocouris, G. Moore, J. Matsoukas."Structural Comparison Between Type I and Type II Antagonists: Possible Implications in the Drug Design of  AT1"  Bioorg. Med. Chem. Letters 10, 2000, 1-4.

 5. T. Tselios, I. Daliani, L. Probert, S. Deraos, E. Matsouka, S. Roy, J. Pires, G. Moore, J. Matsoukas. "Treatment of Experimental Allergic Encephalomyelitis (EAE) Induced by Myelin Basic Epitope MBP72-85 with Linear and Cyclic Analogues of MBP87-89". Bioorg. Med. Chem. 8, 2000, 1903-1909.

6. T. Tselios, I. Daliani, S. Deraos, S. Thymianou, E. Matsouka, A. Troganis, I. Gerothanassis, A. Mouzaki, T. Mavromoustakos, L. Probert, J. Matsoukas. "Treatment of Experimental Allergic Encephalomyelitis (EAE) by a rationally designed cyclic analogue of Myelin Basic Protein (MBP) epitope 72-85".  Bioorg. Med. Chem. Let., 2000, 1-7, In Press.

7.  K. Alexopoulos, D. Panagiotopoulos, P. Roumelioti, T. Mavromoustakos, M.C. Paredes-Carbajal, D. Mascher, S. Mihailescu, J. Matsoukas. "Design, Synthesis and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide analogues of the Ser42 -Phe-Leu-Arg46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH2 Cluster for Receptor Activation and Implications in the Design of Non-Peptide Thrombin Receptor Mimetics". J. Med. Chem., 2000, In Press.